Britton Chance (1913-2010) was a biochemist and biophysicist as well as a pioneer in the field of biomedical optics. Chance received his Ph.D. in Physical Chemistry from the University of Pennsylvania in 1940 and his Ph.D. in Biology and Physiology from Cambridge University in 1942. Over the course of his nearly eight decade career, Chance was dedicated to the application and transfer of basic scientific research and technology to clinical medicine. The Britton Chance Papers contain correspondence, research notes, experimental data, publication materials, and photographs stemming from Chance's life as a biochemist, biophysicist, and yachtsman. The collection is broken up into fifteen series that document every aspect of his scientific work.

A pioneer biochemist, Carl Neuberg (1877-1956) spent over thirty years of his productive career as a professor at the University of Berlin (1903-1937) and as Director of the Kaiser Wilhelm Institutes of Biochemistry and Experimental Therapy. His varied research interests resulted in important contributions to the understanding of fermentation processes, solubility and transport phenomena in cells, the chemistry of carbohydrates, sugars, enzymes, and amino acids, and photochemistry. Neuberg was forced out of his position after the Nazi rise to power, and taking refuge in the United States. For the last several years of his life, he worked at New York University. The Neuberg collection consists of correspondence, lab notebooks, documents, photographs, and reprints, nearly all dating from after Neuberg's departure from Germany in 1940. The correspondence documents Neuberg's late-career work and the contacts he developed with American chemical manufacturers and industries involved in fermentation, as well as the burgeoning post-war relationship between scientific research and the federal dollar. Files for the American Cancer Society, U.S. Atomic Energy Commission, and the U.S. Public Health Service in particular contain useful information for study of the politics and mechanics of government grants.